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SNX2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60749
Clone Names 100528083
Peptide ID 100528083
Additional Information
Gene ID 6643
Other Names Sorting nexin-2, Transformation-related gene 9 protein, TRG-9, SNX2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNX2
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).
Cellular Location Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901).
Research Areas
Citations (0)

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This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein associates with formin-binding protein17, but its function is unknown. This protein may form oligomericcomplexes with family members.


Skanland, S.S., et al. Traffic 8(3):297-309(2007)Rojas, R., et al. Mol. Cell. Biol. 27(3):1112-1124(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Carlton, J.G., et al. J. Cell. Sci. 118 (PT 19), 4527-4539 (2005) :Abdul-Ghani, M., et al. J. Cell. Physiol. 204(1):210-218(2005)

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$ 80.00
Cat# BP16134b
(40 western blots)
Availability: In Stock
Bulk Size
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