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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   RFXANK Antibody (Center) Blocking Peptide   

RFXANK Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14593
Clone Names 100528138
Peptide ID 100528138
Additional Information
Gene ID 8625
Other Names DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, RFX-B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, ANKRA1, RFXB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ANKRA1, RFXB
Function Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9Z205}. Nucleus {ECO:0000250|UniProtKB:Q9Z205}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Major histocompatibility (MHC) class II molecules aretransmembrane proteins that have a central role in development andcontrol of the immune system. The protein encoded by this gene,along with regulatory factor X-associated protein and regulatoryfactor-5, forms a complex that binds to the X box motif of certainMHC class II gene promoters and activates their transcription. Oncebound to the promoter, this complex associates with thenon-DNA-binding factor MHC class II transactivator, which controlsthe cell type specificity and inducibility of MHC class II geneexpression. This protein contains ankyrin repeats involved inprotein-protein interactions. Mutations in this gene have beenlinked to bare lymphocyte syndrome type II, complementation groupB. Two transcript variants encoding different isoforms have beendescribed for this gene, with only one isoform showing activationactivity.


Garvie, C.W., et al. Biochim. Biophys. Acta 1779(12):797-804(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Krawczyk, M., et al. Mol. Cell. Biol. 25(19):8607-8618(2005)Wang, A.H., et al. J. Biol. Chem. 280(32):29117-29127(2005)Grimwood, J., et al. Nature 428(6982):529-535(2004)

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$ 80.00
Cat# BP16143c
Availability: In Stock
Bulk Size
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