|Other Names||DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, RFX-B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, ANKRA1, RFXB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.|
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Provided below are standard protocols that you may find useful for product applications.
Major histocompatibility (MHC) class II molecules aretransmembrane proteins that have a central role in development andcontrol of the immune system. The protein encoded by this gene,along with regulatory factor X-associated protein and regulatoryfactor-5, forms a complex that binds to the X box motif of certainMHC class II gene promoters and activates their transcription. Oncebound to the promoter, this complex associates with thenon-DNA-binding factor MHC class II transactivator, which controlsthe cell type specificity and inducibility of MHC class II geneexpression. This protein contains ankyrin repeats involved inprotein-protein interactions. Mutations in this gene have beenlinked to bare lymphocyte syndrome type II, complementation groupB. Two transcript variants encoding different isoforms have beendescribed for this gene, with only one isoform showing activationactivity.
Garvie, C.W., et al. Biochim. Biophys. Acta 1779(12):797-804(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Krawczyk, M., et al. Mol. Cell. Biol. 25(19):8607-8618(2005)Wang, A.H., et al. J. Biol. Chem. 280(32):29117-29127(2005)Grimwood, J., et al. Nature 428(6982):529-535(2004)
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