|Other Names||Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, CACNB1, CACNLB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the calciumchannel beta subunit family. It plays an important role in thecalcium channel by modulating G protein inhibition, increasing peakcalcium current, controlling the alpha-1 subunit membrane targetingand shifting the voltage dependence of activation and inactivation.Alternative splicing occurs at this locus and three transcriptvariants encoding three distinct isoforms have been identified.
Jangsangthong, W., et al. Pflugers Arch. 459(3):399-411(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)Foell, J.D., et al. Physiol. Genomics 17(2):183-200(2004)
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