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CACNB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q02641
Clone Names 100528149
Additional Information
Gene ID 782
Other Names Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, CACNB1, CACNLB1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CACNB1
Synonyms CACNLB1
Function Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).
Cellular Location Cell membrane, sarcolemma; Peripheral membrane protein {ECO:0000250|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250|UniProtKB:P19517}. Cell membrane; Peripheral membrane protein
Tissue Location Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene belongs to the calciumchannel beta subunit family. It plays an important role in thecalcium channel by modulating G protein inhibition, increasing peakcalcium current, controlling the alpha-1 subunit membrane targetingand shifting the voltage dependence of activation and inactivation.Alternative splicing occurs at this locus and three transcriptvariants encoding three distinct isoforms have been identified.

References

Jangsangthong, W., et al. Pflugers Arch. 459(3):399-411(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)Foell, J.D., et al. Physiol. Genomics 17(2):183-200(2004)

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$ 277.78
Cat# BP16144b
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