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NR2C1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13056 |
|---|---|
| Clone Names | 100528170 |
| Gene ID | 7181 |
|---|---|
| Other Names | Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NR2C1 |
|---|---|
| Synonyms | TR2 |
| Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body. Note=Recruited by HDAC3, after all- trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear hormone receptor characterizedby a highly conserved DNA binding domain (DBD), a variable hingeregion, and a carboxy-terminal ligand binding domain (LBD) that istypical for all members of the steroid/thyroid hormone receptorsuperfamily. This protein also belongs to a large family ofligand-inducible transcription factors that regulate geneexpression by binding to specific DNA sequences within promoters oftarget genes. Multiple alternatively spliced transcript variantshave been described, but the full-length nature of some of thesevariants has not been determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lin, Y.L., et al. Biochem. Biophys. Res. Commun. 350(2):430-436(2006)Li, G., et al. Biochem. Biophys. Res. Commun. 310(2):384-390(2003)Mu, X., et al. Prostate 57(2):129-133(2003)Franco, P.J., et al. Mol. Endocrinol. 15(8):1318-1328(2001)
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