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NR2C1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P13056
Clone Names 100528170
Peptide ID 100528170
Additional Information
Gene ID 7181
Other Names Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2C1
Synonyms TR2
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation
Research Areas
Citations (0)

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This gene encodes a nuclear hormone receptor characterizedby a highly conserved DNA binding domain (DBD), a variable hingeregion, and a carboxy-terminal ligand binding domain (LBD) that istypical for all members of the steroid/thyroid hormone receptorsuperfamily. This protein also belongs to a large family ofligand-inducible transcription factors that regulate geneexpression by binding to specific DNA sequences within promoters oftarget genes. Multiple alternatively spliced transcript variantshave been described, but the full-length nature of some of thesevariants has not been determined.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lin, Y.L., et al. Biochem. Biophys. Res. Commun. 350(2):430-436(2006)Li, G., et al. Biochem. Biophys. Res. Commun. 310(2):384-390(2003)Mu, X., et al. Prostate 57(2):129-133(2003)Franco, P.J., et al. Mol. Endocrinol. 15(8):1318-1328(2001)

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$ 80.00
Cat# BP16146b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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