SOX11 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35716 |
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Clone Names | 100528179 |
Gene ID | 6664 |
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Other Names | Transcription factor SOX-11, SOX11 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SOX11 |
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Function | Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:35938035} |
Tissue Location | Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This intronless gene encodes a member of the SOX(SRY-related HMG-box) family of transcription factors involved inthe regulation of embryonic development and in the determination ofthe cell fate. The encoded protein may act as a transcriptionalregulator after forming a protein complex with other proteins. Theprotein may function in the developing nervous system and play arole in tumorigenesis.
References
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Fernandez, V., et al. Cancer Res. 70(4):1408-1418(2010)Dictor, M., et al. Haematologica 94(11):1563-1568(2009)Mozos, A., et al. Haematologica 94(11):1555-1562(2009)Hide, T., et al. Cancer Res. 69(20):7953-7959(2009)
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