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MAFA Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NHW3
Clone Names 100528182
Additional Information
Gene ID 389692
Other Names Transcription factor MafA, Pancreatic beta-cell-specific transcriptional activator, Transcription factor RIPE3b1, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAFA
Function Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12917329}
Tissue Location Expressed in the islets of Langerhans (at protein level).
Research Areas
Citations (0)
citation

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Background

MAFA is a transcription factor that binds RIPE3b, aconserved enhancer element that regulates pancreatic betacell-specific expression of the insulin gene (INS; MIM 176730)(Olbrot et al., 2002 [PubMed 12011435]).

References

Lecoin, L., et al. Dev Neurobiol 70(7):485-497(2010)Guo, S., et al. J. Biol. Chem. 285(17):12655-12661(2010)Kondo, T., et al. Mol. Endocrinol. 23(8):1281-1290(2009)Kaneto, H., et al. Adv. Drug Deliv. Rev. 61 (7-8), 489-496 (2009) :Garin, I., et al. Diabet. Med. 26(7):746-748(2009)

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$ 277.78
Cat# BP16148b
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