|Other Names||ATP-binding cassette sub-family E member 1, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, ABCE1, RLI, RNASEL1, RNASELI, RNS4I|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||RLI, RNASEL1, RNASELI, RNS4I|
|Function||Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the OABP subfamily. Alternatively referredto as the RNase L inhibitor, this protein functions to block theactivity of ribonuclease L. Activation of ribonuclease L leads toinhibition of protein synthesis in the 2-5A/RNase L system, thecentral pathway for viral interferon action. Two transcriptvariants encoding the same protein have been found for this gene.
Huang, B., et al. Int. J. Mol. Med. 25(5):687-693(2010)Pisarev, A.V., et al. Mol. Cell 37(2):196-210(2010)Crawford, D.C., et al. Genes Immun. 10(8):715-721(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Shea, P.R., et al. Prostate 68(4):354-359(2008)
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