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ABCE1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P61221
Clone Names 100528085
Peptide ID 100528085
Additional Information
Gene ID 6059
Other Names ATP-binding cassette sub-family E member 1, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, ABCE1, RLI, RNASEL1, RNASELI, RNS4I
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCE1
Function Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Cellular Location Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the OABP subfamily. Alternatively referredto as the RNase L inhibitor, this protein functions to block theactivity of ribonuclease L. Activation of ribonuclease L leads toinhibition of protein synthesis in the 2-5A/RNase L system, thecentral pathway for viral interferon action. Two transcriptvariants encoding the same protein have been found for this gene.


Huang, B., et al. Int. J. Mol. Med. 25(5):687-693(2010)Pisarev, A.V., et al. Mol. Cell 37(2):196-210(2010)Crawford, D.C., et al. Genes Immun. 10(8):715-721(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Shea, P.R., et al. Prostate 68(4):354-359(2008)

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$ 80.00
Cat# BP16149b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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