|Other Names||Interleukin-1 receptor-associated kinase-like 2, IRAK-2, mu-IRAK-2, Irak2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|
|Tissue Location||Ubiquitously expressed, with a higher expression observed in brain, spleen and liver. Isoform 1 and isoform 2 are considered agonist and isoform 3 and isoform 4 are considered antagonist|
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Provided below are standard protocols that you may find useful for product applications.
Irak2 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization (By similarity).
Hou, J., et al. J. Immunol. 183(3):2150-2158(2009)Conner, J.R., et al. J. Exp. Med. 206(7):1615-1631(2009)Wan, Y., et al. J. Biol. Chem. 284(16):10367-10375(2009)Elzinga, B.M., et al. J. Biol. Chem. 284(3):1394-1409(2009)Kawagoe, T., et al. Nat. Immunol. 9(6):684-691(2008)
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