|Other Names||STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog, ILP-interacting protein homolog, Polyploidy-associated protein kinase, Pseudokinase ALS2CR2, Stradb, Als2cr2, Papk, Syradb|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Als2cr2, Papk, Syradb|
|Function||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.
Ling, K.H., et al. Genome Biol. 10 (10), R104 (2009) :Barnes, A.P., et al. Cell 129(3):549-563(2007)Nishigaki, K., et al. J. Biol. Chem. 278(15):13520-13530(2003)Welch, C.L., et al. Mamm. Genome 8(8):620-621(1997)Welch, C.L., et al. J. Lipid Res. 37(7):1406-1421(1996)
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