|Other Names||Homeobox protein Hox-B8, Homeobox protein Hox-24, Homeobox protein Hox-2D, HOXB8, HOX2D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
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This gene is a member of the Antp homeobox family andencodes a nuclear protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox B genes located on chromosome 17.The encoded protein functions as a sequence-specific transcriptionfactor that is involved in development. Increased expression ofthis gene is associated with colorectal cancer. Mice that have hadthe murine ortholog of this gene knocked out exhibit an excessivepathologic grooming behavior. This behavior is similar to thebehavior of humans suffering from the obsessive-compulsive spectrumdisorder trichotillomania.
Kosaki, K., et al. Teratology 65(2):50-62(2002)Greer, J.M., et al. Neuron 33(1):23-34(2002)Knoepfler, P.S., et al. Oncogene 20(39):5440-5448(2001)Fujino, T., et al. Exp. Hematol. 29(7):856-863(2001)Vider, B.Z., et al. Biochem. Biophys. Res. Commun. 232(3):742-748(1997)
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