|Other Names||Arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein, Nucleoporin-like protein RIP, Rev-interacting protein, Rev/Rex activation domain-binding protein, AGFG1, HRB, RAB, RIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HRB, RAB, RIP|
|Function||Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.|
|Cellular Location||Nucleus. Cytoplasmic vesicle.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is related tonucleoporins, a class of proteins that mediate nucleocytoplasmictransport. The encoded protein binds the activation domain of thehuman immunodeficiency virus Rev protein when Rev is assembled ontoits RNA target, and is required for the nuclear export ofRev-directed RNAs. Multiple transcript variants encoding differentisoforms have been found for this gene.
Bowes, J.D., et al. Pharmacogenet. Genomics 19(4):319-323(2009)Chaineau, M., et al. J. Biol. Chem. 283(49):34365-34373(2008)Pryor, P.R., et al. Cell 134(5):817-827(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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