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SMARCD1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96GM5
Clone Names 100318129
Peptide ID 100318129
Additional Information
Gene ID 6602
Other Names SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, 60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, SWI/SNF complex 60 kDa subunit, SMARCD1 {ECO:0000312|EMBL:AAD233901}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMARCD1 {ECO:0000312|EMBL:AAD23390.1}
Function Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.
Cellular Location Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305}
Tissue Location Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theSWI/SNF family of proteins, whose members display helicase andATPase activities and which are thought to regulate transcriptionof certain genes by altering the chromatin structure around thosegenes. The encoded protein is part of the large ATP-dependentchromatin remodeling complex SNF/SWI and has sequence similarity tothe yeast Swp73 protein. Two transcript variants encoding differentisoforms have been found for this gene.


van de Wijngaart, D.J., et al. Mol. Endocrinol. 23(11):1776-1786(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006)Hsiao, P.W., et al. Mol. Cell. Biol. 23(17):6210-6220(2003)Kitagawa, H., et al. Cell 113(7):905-917(2003)

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$ 80.00
Cat# BP16186b
(40 western blots)
Availability: In Stock
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