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PIGT Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q969N2 |
|---|---|
| Clone Names | 100318225 |
| Gene ID | 51604 |
|---|---|
| Other Names | GPI transamidase component PIG-T, Phosphatidylinositol-glycan biosynthesis class T protein, PIGT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIGT |
|---|---|
| Function | Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is involved inglycosylphosphatidylinositol (GPI)-anchor biosynthesis. TheGPI-anchor is a glycolipid found on many blood cells and serves toanchor proteins to the cell surface. This protein is an essentialcomponent of the multisubunit enzyme, GPI transamidase. GPItransamidase mediates GPI anchoring in the endoplasmic reticulum,by catalyzing the transfer of fully assembled GPI units toproteins. Several transcript variants encoding different isoformshave been found for this gene.
References
Li, H.L., et al. FEBS Lett. 580(7):1723-1728(2006)Vainauskas, S., et al. J. Biol. Chem. 280(16):16402-16409(2005)Ohishi, K., et al. J. Biol. Chem. 278(16):13959-13967(2003)Eisenhaber, B., et al. Bioessays 25(4):367-385(2003)Vainauskas, S., et al. J. Biol. Chem. 277(34):30535-30542(2002)
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