|Other Names||GPI transamidase component PIG-T, Phosphatidylinositol-glycan biosynthesis class T protein, PIGT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is involved inglycosylphosphatidylinositol (GPI)-anchor biosynthesis. TheGPI-anchor is a glycolipid found on many blood cells and serves toanchor proteins to the cell surface. This protein is an essentialcomponent of the multisubunit enzyme, GPI transamidase. GPItransamidase mediates GPI anchoring in the endoplasmic reticulum,by catalyzing the transfer of fully assembled GPI units toproteins. Several transcript variants encoding different isoformshave been found for this gene.
Li, H.L., et al. FEBS Lett. 580(7):1723-1728(2006)Vainauskas, S., et al. J. Biol. Chem. 280(16):16402-16409(2005)Ohishi, K., et al. J. Biol. Chem. 278(16):13959-13967(2003)Eisenhaber, B., et al. Bioessays 25(4):367-385(2003)Vainauskas, S., et al. J. Biol. Chem. 277(34):30535-30542(2002)
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