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EDARADD Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WWZ3 |
|---|---|
| Clone Names | 100406094 |
| Gene ID | 128178 |
|---|---|
| Other Names | Ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, Protein crinkled homolog, EDARADD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EDARADD |
|---|---|
| Function | Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified by its association withectodermal dysplasia, a genetic disorder characterized by defectivedevelopment of hair, teeth, and eccrine sweat glands. The proteinencoded by this gene is a death domain-containing protein, and isfound to interact with EDAR, a death domain receptor known to berequired for the development of hair, teeth and other ectodermalderivatives. This protein and EDAR are coexpressed in epithelialcells during the formation of hair follicles and teeth. Through itsinteraction with EDAR, this protein acts as an adaptor, and linksthe receptor to downstream signaling pathways. Two alternativelyspliced transcript variants of this gene encoding distinct isoformshave been reported.
References
Chassaing, N., et al. Br. J. Dermatol. 162(5):1044-1048(2010)Thesleff, I., et al. Sci. STKE 2002 (131), PE22 (2002) :Yan, M., et al. Curr. Biol. 12(5):409-413(2002)Headon, D.J., et al. Nature 414(6866):913-916(2001)Kumar, A., et al. J. Biol. Chem. 276(4):2668-2677(2001)
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