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EDARADD Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8WWZ3
Clone Names 100406094
Peptide ID 100406094
Additional Information
Gene ID 128178
Other Names Ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, Protein crinkled homolog, EDARADD
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF- kappa-B.
Cellular Location Cytoplasm.
Tissue Location Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis
Research Areas
Citations (0)

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This gene was identified by its association withectodermal dysplasia, a genetic disorder characterized by defectivedevelopment of hair, teeth, and eccrine sweat glands. The proteinencoded by this gene is a death domain-containing protein, and isfound to interact with EDAR, a death domain receptor known to berequired for the development of hair, teeth and other ectodermalderivatives. This protein and EDAR are coexpressed in epithelialcells during the formation of hair follicles and teeth. Through itsinteraction with EDAR, this protein acts as an adaptor, and linksthe receptor to downstream signaling pathways. Two alternativelyspliced transcript variants of this gene encoding distinct isoformshave been reported.


Chassaing, N., et al. Br. J. Dermatol. 162(5):1044-1048(2010)Thesleff, I., et al. Sci. STKE 2002 (131), PE22 (2002) :Yan, M., et al. Curr. Biol. 12(5):409-413(2002)Headon, D.J., et al. Nature 414(6866):913-916(2001)Kumar, A., et al. J. Biol. Chem. 276(4):2668-2677(2001)

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$ 80.00
Cat# BP16194b
Availability: In Stock
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