|Other Names||DDB1- and CUL4-associated factor 12, Centrosome-related protein TCC52, Testis cancer centrosome-related protein, WD repeat-containing protein 40A, DCAF12, KIAA1892, TCC52, WDR40A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1892, TCC52, WDR40A|
|Function||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
|Tissue Location||Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a WD repeat-containing protein thatinteracts with the COP9 signalosome, a macromolecular complex thatinteracts with cullin-RING E3 ligases and regulates their activityby hydrolyzing cullin-Nedd8 conjugates.
Olma, M.H., et al. J. Cell. Sci. 122 (PT 7), 1035-1044 (2009) :Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :Li, S., et al. Cancer Sci. 99(11):2274-2279(2008)Bernstein, D., et al. J. Heart Lung Transplant. 26(12):1270-1280(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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