|Other Names||THAP domain-containing protein 11, THAP11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a THAP domain,which is a conserved DNA-binding domain that has strikingsimilarity to the site-specific DNA-binding domain (DBD) ofDrosophila P element transposases.
Zhu, C.Y., et al. Cell Death Differ. 16(3):395-405(2009)Dejosez, M., et al. Cell 133(7):1162-1174(2008)Roussigne, M., et al. Trends Biochem. Sci. 28(2):66-69(2003)Ueki, N., et al. Nat. Biotechnol. 16(13):1338-1342(1998)Li, S.H., et al. Genomics 16(3):572-579(1993)
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