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C9orf46 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HBL7
Clone Names 100406236
Peptide ID 100406236
Additional Information
Other Names Plasminogen receptor (KT), Plg-R(KT), PLGRKT, C9orf46
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLGRKT
Synonyms C9orf46
Function Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.
Cellular Location Cell membrane; Multi-pass membrane protein Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR.
Tissue Location Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla EMBL; AF225420; AAG09722.1; -; mRNA EMBL; AF220050; AAF67643.1; -; mRNA EMBL; AK027594; BAB55219.1; -; mRNA EMBL; AK312736; BAG35607.1; -; mRNA EMBL; AL135786; CAH70364.1; -; Genomic_DNA EMBL; CH471071; EAW58765.1; -; Genomic_DNA EMBL; BC008212; AAH08212.1; -; mRNA CCDS; CCDS6463.1; - RefSeq; NP_060935.2; NM_018465.3 RefSeq; XP_005251567.1; XM_005251510.4 RefSeq; XP_011516262.1; XM_011517960.2 UniGene; Hs.584242; - ProteinModelPortal; Q9HBL7; - BioGrid; 120950; 5 IntAct; Q9HBL7; 6 MINT; MINT-1401294; - STRING; 9606.ENSP00000223864; - iPTMnet; Q9HBL7; - PhosphoSitePlus; Q9HBL7; - BioMuta; PLGRKT; - DMDM; 68565305; - EPD; Q9HBL7; - MaxQB; Q9HBL7; - PaxDb; Q9HBL7; - PeptideAtlas; Q9HBL7; - PRIDE; Q9HBL7; - TopDownProteomics; Q9HBL7; - DNASU; 55848; - Ensembl; ENST00000223864; ENSP00000223864; ENSG00000107020 GeneID; 55848; - KEGG; hsa:55848; - UCSC; uc003zjc.5; human CTD; 55848; - DisGeNET; 55848; - GeneCards; PLGRKT; - H-InvDB; HIX0007899; - HGNC; HGNC:23633; PLGRKT HPA; HPA008214; - HPA; HPA011144; - neXtProt; NX_Q9HBL7; - OpenTargets; ENSG00000107020; - PharmGKB; PA134964114; - eggNOG; KOG4544; Eukaryota eggNOG; ENOG4111K7G; LUCA GeneTree; ENSGT00390000000375; - HOGENOM; HOG000007140; - HOVERGEN; HBG081159; - InParanoid; Q9HBL7; - OMA; MQNEMRE; - OrthoDB; EOG091G0RJ6; - PhylomeDB; Q9HBL7; - TreeFam; TF314698; - BioCyc; ZFISH:ENSG00000107020-MONOMER; - GenomeRNAi; 55848; - PRO; PR:Q9HBL7; - Proteomes; UP000005640; Chromosome 9 Bgee; ENSG00000107020; - CleanEx; HS_C9orf46; - Genevisible; Q9HBL7; HS GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl GO; GO:0005739; C:mitochondrion; IEA:Ensembl GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW GO; GO:0010756; P:positive regulation of plasminogen activation; IEA:Ensembl InterPro; IPR019319; DUF2368 PANTHER; PTHR13411; PTHR13411; 1 Pfam; PF10166; DUF2368; 1 1: Evidence at protein level; Cell membrane; Chemotaxis; Complete proteome; Inflammatory response; Membrane; Plasminogen activation; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 147 Plasminogen receptor (KT) /FTId=PRO_0000089695 TOPO_DOM 1 52 Extracellular. TRANSMEM 53 73 Helical. TOPO_DOM 74 78 Cytoplasmic. TRANSMEM 79 99 Helical. TOPO_DOM 100 147 Extracellular. CONFLICT 46 46 Q -> R (in Ref. 2; AAF67643) SEQUENCE 147 AA; 17201 MW; BF096D76E8F2F806 CRC64; MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS REFLKYFGTF FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG TLLERMKGEA EDILETEKSK LQLPRGMITF ESIEKARKEQ SRFFIDK
Research Areas
Citations (0)

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Background

The exact function of C9ORF46 remains unknown.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Humphray, S.J., et al. Nature 429(6990):369-374(2004)

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$ 80.00
Cat# BP16198b
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