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DNAH2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P225
Clone Names 100422060
Additional Information
Gene ID 146754
Other Names Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNAH2 (HGNC:2948)
Synonyms DNAHC2, DNHD3, KIAA1503
Function As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583).
Cellular Location Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme
Tissue Location Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung Expressed in spermatozoa (at protein level) (PubMed:31178125)
Research Areas
Citations (0)
citation

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Background

Dyneins are microtubule-associated motor protein complexescomposed of several heavy, light, and intermediate chains. Theaxonemal dyneins, found in cilia and flagella, are components ofthe outer and inner dynein arms attached to the peripheralmicrotubule doublets. DNAH2 is an axonemal inner arm dynein heavychain (Chapelin et al., 1997 [PubMed 9256245]).

References

Barrett, J.C., et al. Nat. Genet. (2009) In press :Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :Chapelin, C., et al. FEBS Lett. 412(2):325-330(1997)

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$ 277.78
Cat# BP16211a
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