DNAH2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9P225 |
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Clone Names | 100422060 |
Gene ID | 146754 |
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Other Names | Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNAH2 (HGNC:2948) |
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Synonyms | DNAHC2, DNHD3, KIAA1503 |
Function | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). |
Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme |
Tissue Location | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung Expressed in spermatozoa (at protein level) (PubMed:31178125) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Dyneins are microtubule-associated motor protein complexescomposed of several heavy, light, and intermediate chains. Theaxonemal dyneins, found in cilia and flagella, are components ofthe outer and inner dynein arms attached to the peripheralmicrotubule doublets. DNAH2 is an axonemal inner arm dynein heavychain (Chapelin et al., 1997 [PubMed 9256245]).
References
Barrett, J.C., et al. Nat. Genet. (2009) In press :Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :Chapelin, C., et al. FEBS Lett. 412(2):325-330(1997)
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