|Other Names||Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DNAHC2, DNHD3, KIAA1503|
|Function||Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, cilium axoneme|
|Tissue Location||Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung|
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Dyneins are microtubule-associated motor protein complexescomposed of several heavy, light, and intermediate chains. Theaxonemal dyneins, found in cilia and flagella, are components ofthe outer and inner dynein arms attached to the peripheralmicrotubule doublets. DNAH2 is an axonemal inner arm dynein heavychain (Chapelin et al., 1997 [PubMed 9256245]).
Barrett, J.C., et al. Nat. Genet. (2009) In press :Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :Chapelin, C., et al. FEBS Lett. 412(2):325-330(1997)
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