|Other Names||Ankyrin repeat and KH domain-containing protein 1, HIV-1 Vpr-binding ankyrin repeat protein, Multiple ankyrin repeats single KH domain, hMASK, ANKHD1, KIAA1085, MASK, VBARP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1085, MASK, VBARP|
|Function||May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.|
|Tissue Location||Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain|
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Provided below are standard protocols that you may find useful for product applications.
The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturallyoccurring readthrough transcript of the neighboring ANKHD1 andEIF4EBP3 genes. This readthrough transcript encodes a proteincomposed mostly of the multiple ankyrin repeats, single KH-domainprotein, with its C-terminus encoded in a different reading framefrom the shared portion of the EIF4EBP3 gene. The significance ofthis readthrough mRNA and the function of its protein product havenot yet been determined.
Prakash, T., et al. PLoS ONE 5 (10), E13284 (2010) :Santos Duarte Ada, S., et al. Gene 363, 113-122 (2005) :Poulin, F., et al. J. Biol. Chem. 278(52):52290-52297(2003)
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