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NCOA4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13772 |
|---|---|
| Clone Names | 100617294 |
| Gene ID | 8031 |
|---|---|
| Other Names | Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCOA4 |
|---|---|
| Synonyms | ARA70, ELE1, RFG |
| Function | Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. |
| Tissue Location | Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an androgen receptor coactivator. Theencoded protein interacts with the androgen receptor in aligand-dependent manner to enhance its transcriptional activity.Chromosomal translocations between this gene and the ret tyrosinekinase gene, also located on chromosome 10, have been associatedwith papillary thyroid carcinoma.
References
Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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