|Other Names||Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARA70, ELE1, RFG|
|Function||Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.|
|Tissue Location||Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis|
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This gene encodes an androgen receptor coactivator. Theencoded protein interacts with the androgen receptor in aligand-dependent manner to enhance its transcriptional activity.Chromosomal translocations between this gene and the ret tyrosinekinase gene, also located on chromosome 10, have been associatedwith papillary thyroid carcinoma.
Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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