|Other Names||Splicing factor, suppressor of white-apricot homolog, Splicing factor, arginine/serine-rich 8, Suppressor of white apricot protein homolog, SFSWAP, SFRS8, SWAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a human homolog of Drosophila splicingregulatory protein. This gene autoregulates its expression bycontrol of splicing of its first two introns. In addition, it alsoregulates the splicing of fibronectin and CD45 genes.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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