Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
L1CAM Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P32004 |
|---|---|
| Clone Names | 90415107 |
| Gene ID | 3897 |
|---|---|
| Other Names | Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | L1CAM |
|---|---|
| Synonyms | CAML1, MIC5 |
| Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Cell projection, axon. Cell projection, dendrite Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658) {ECO:0000250|UniProtKB:Q05695, ECO:0000269|PubMed:20621658} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
L1CAM is an axonal glycoproteinbelonging to the immunoglobulin supergene family. The ectodomain,consisting of several immunoglobulin-like domains andfibronectin-like repeats (type III), is linked via a singletransmembrane sequence to a conserved cytoplasmic domain. This celladhesion molecule plays an important role in nervous systemdevelopment, including neuronal migration and differentiation.Mutations in the gene cause three X-linked neurological syndromesknown by the acronym CRASH (corpus callosum hypoplasia,retardation, aphasia, spastic paraplegia and hydrocephalus).Alternative splicing of a neuron-specific exon is thought to befunctionally relevant.
References
Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)Gavert, N., et al. J. Cell. Sci. 123 (PT 12), 2135-2143 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
