|Other Names||Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
L1CAM is an axonal glycoproteinbelonging to the immunoglobulin supergene family. The ectodomain,consisting of several immunoglobulin-like domains andfibronectin-like repeats (type III), is linked via a singletransmembrane sequence to a conserved cytoplasmic domain. This celladhesion molecule plays an important role in nervous systemdevelopment, including neuronal migration and differentiation.Mutations in the gene cause three X-linked neurological syndromesknown by the acronym CRASH (corpus callosum hypoplasia,retardation, aphasia, spastic paraplegia and hydrocephalus).Alternative splicing of a neuron-specific exon is thought to befunctionally relevant.
Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)Gavert, N., et al. J. Cell. Sci. 123 (PT 12), 2135-2143 (2010) :
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