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CDC42SE2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NRR3 |
|---|---|
| Clone Names | 90429066 |
| Gene ID | 56990 |
|---|---|
| Other Names | CDC42 small effector protein 2, Small effector of CDC42 protein 2, CDC42SE2, SPEC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDC42SE2 |
|---|---|
| Synonyms | SPEC2 |
| Function | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell membrane; Lipid- anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages |
| Tissue Location | Widely expressed. Expressed at higher level in T- lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T- lymphocytes, and Raji B-lymphocytes compared (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDC42SE2 is probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
References
Edwards, T.L., et al. Schizophr. Res. 106 (2-3), 208-217 (2008) :Chen, X., et al. Hum. Mol. Genet. 15(22):3329-3342(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Ching, K.H., et al. J. Biol. Chem. 280(25):23660-23667(2005)Pirone, D.M., et al. J. Biol. Chem. 275(30):22650-22656(2000)
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