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CDC42SE2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NRR3
Clone Names 90429066
Peptide ID 90429066
Additional Information
Gene ID 56990
Other Names CDC42 small effector protein 2, Small effector of CDC42 protein 2, CDC42SE2, SPEC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42SE2
Synonyms SPEC2
Function Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Cellular Location Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages
Tissue Location Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level)
Research Areas
Citations (0)

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Background

CDC42SE2 is probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

References

Edwards, T.L., et al. Schizophr. Res. 106 (2-3), 208-217 (2008) :Chen, X., et al. Hum. Mol. Genet. 15(22):3329-3342(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Ching, K.H., et al. J. Biol. Chem. 280(25):23660-23667(2005)Pirone, D.M., et al. J. Biol. Chem. 275(30):22650-22656(2000)

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$ 80.00
Cat# BP16223a
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