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IGBP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P78318 |
|---|---|
| Clone Names | 100528134 |
| Gene ID | 3476 |
|---|---|
| Other Names | Immunoglobulin-binding protein 1, B-cell signal transduction molecule alpha 4, Protein alpha-4, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit, Renal carcinoma antigen NY-REN-16, IGBP1, IBP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IGBP1 |
|---|---|
| Synonyms | IBP1 |
| Function | Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The proliferation and differentiation of B cells isdependent upon a B-cell antigen receptor (BCR) complex. Binding ofantigens to specific B-cell receptors results in a tyrosinephosphorylation reaction through the BCR complex and leads tomultiple signal transduction pathways.
References
McDonald, W.J., et al. J. Cell. Biochem. 110(5):1123-1129(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Fielhaber, J.A., et al. J. Biol. Chem. 284(36):24341-24353(2009)Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)Aranda-Orgilles, B., et al. PLoS ONE 3 (10), E3507 (2008) :
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