|Other Names||Immunoglobulin-binding protein 1, B-cell signal transduction molecule alpha 4, Protein alpha-4, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit, Renal carcinoma antigen NY-REN-16, IGBP1, IBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.|
|Tissue Location||Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The proliferation and differentiation of B cells isdependent upon a B-cell antigen receptor (BCR) complex. Binding ofantigens to specific B-cell receptors results in a tyrosinephosphorylation reaction through the BCR complex and leads tomultiple signal transduction pathways.
McDonald, W.J., et al. J. Cell. Biochem. 110(5):1123-1129(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Fielhaber, J.A., et al. J. Biol. Chem. 284(36):24341-24353(2009)Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)Aranda-Orgilles, B., et al. PLoS ONE 3 (10), E3507 (2008) :
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