|Other Names||Hydroxycarboxylic acid receptor 1, G-protein coupled receptor 104, G-protein coupled receptor 81, HCAR1, GPR104, GPR81, HCA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR104, GPR81, HCA1|
|Function||Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs), such asGPR81, contain 7 transmembrane domains and transduce extracellularsignals through heterotrimeric G proteins.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Jeninga, E.H., et al. J. Biol. Chem. 284(39):26385-26393(2009)Liu, C., et al. J. Biol. Chem. 284(5):2811-2822(2009)Cai, T.Q., et al. Biochem. Biophys. Res. Commun. 377(3):987-991(2008)
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