|Other Names||Lens fiber membrane intrinsic protein, MP18, MP19, MP20, LIM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Eye lens specific.|
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LIM2 is an eye lens-specific protein found atthe junctions of lens fiber cells, where it may contribute to celljunctional organization. It acts as a receptor for calmodulin, andmay play an important role in both lens development andcataractogenesis. Mutations in this gene have been associated withcataract formation.
Ponnam, S.P., et al. Mol. Vis. 14, 1204-1208 (2008) :Hsu, H., et al. Sheng Wu Gong Cheng Xue Bao 20(4):507-515(2004)Wistow, G., et al. Mol. Vis. 8, 171-184 (2002) :Wistow, G., et al. Mol. Vis. 8, 185-195 (2002) :Pras, E., et al. Am. J. Hum. Genet. 70(5):1363-1367(2002)
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