|Other Names||Mas-related G-protein coupled receptor member X3, Sensory neuron-specific G-protein coupled receptor 1/2, MRGPRX3, MRGX3, SNSR1, SNSR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MRGX3, SNSR1, SNSR2|
|Function||Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons|
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MRGPRX3 is a member of the mas-related/sensoryneuron specific subfamily of G protein coupled receptors. Theencoded protein may be involved in sensory neuron regulation and inthe modulation of pain.
Burstein, E.S., et al. Br. J. Pharmacol. 147(1):73-82(2006)Kaisho, Y., et al. Biochem. Biophys. Res. Commun. 330(3):653-657(2005)Lembo, P.M., et al. Nat. Neurosci. 5(3):201-209(2002)Dong, X., et al. Cell 106(5):619-632(2001)
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