|Other Names||Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein, CD269, TNFRSF17, BCM, BCMA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures|
|Tissue Location||Expressed in mature B-cells, but not in T- cells or monocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is preferentially expressedin mature B lymphocytes, and may be important for B celldevelopment and autoimmune response. This receptor has been shownto specifically bind to the tumor necrosis factor (ligand)superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead toNF-kappaB and MAPK8/JNK activation. This receptor also binds tovarious TRAF family members, and thus may transduce signals forcell survival and proliferation.
Chae, S.C., et al. Mol. Cells 29(1):21-28(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Barone, F., et al. Mucosal Immunol 2(6):495-503(2009)Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)Li, H., et al. PLoS ONE 4 (7), E6410 (2009) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.