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SIGLEC6 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O43699
Other Accession NP_001236
Clone Names 2101904
Peptide ID 2101904
Additional Information
Gene ID 946
Other Names Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1, CD327, SIGLEC6, CD33L, CD33L1, OBBP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1624b was selected from the C-term region of human SIGLEC6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIGLEC6
Synonyms CD33L, CD33L1, OBBP1
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine
Research Areas
Citations (0)

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Background

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

References

Patel, N., et al., J. Biol. Chem. 274(32):22729-22738 (1999).Takei, Y., et al., Cytogenet. Cell Genet. 78 (3-4), 295-300 (1997).Patel, N., et al., J. Biol. Chem. 274, 28058-28058 (1999).

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$ 80.00
Cat# BP1624b
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