|Other Names||Protein CBFA2T2, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, Myeloid translocation-related protein 1, p85, CBFA2T2, EHT, MTGR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.|
|Tissue Location||Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.|
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In acute myeloid leukemia, especially in the M2 subtype,the t(8;21)(q22;q22) translocation is one of the most frequentkaryotypic abnormalities. The translocation produces a chimericgene made up of the 5'-region of the RUNX1 (AML1) gene fused to the3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein isthought to associate with the nuclear corepressor/histonedeacetylase complex to block hematopoietic differentiation. Theprotein encoded by this gene binds to the AML1-MTG8 complex and maybe important in promoting leukemogenesis. Several transcriptvariants are thought to exist for this gene, but the full-lengthnatures of only three have been described.
Guastadisegni, M.C., et al. Leukemia 24(8):1516-1519(2010)Ossovskaya, V.S., et al. J. Neurosci. Methods 177(2):322-333(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Olsson, A., et al. Biochim. Biophys. Acta 1779(10):590-598(2008)Kumar, R., et al. Mol. Cancer Res. 4(9):655-665(2006)
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