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CBFA2T2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43439
Clone Names 100528135
Peptide ID 100528135
Additional Information
Gene ID 9139
Other Names Protein CBFA2T2, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, Myeloid translocation-related protein 1, p85, CBFA2T2, EHT, MTGR1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBFA2T2
Synonyms EHT, MTGR1
Function May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
Research Areas
Citations (0)

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In acute myeloid leukemia, especially in the M2 subtype,the t(8;21)(q22;q22) translocation is one of the most frequentkaryotypic abnormalities. The translocation produces a chimericgene made up of the 5'-region of the RUNX1 (AML1) gene fused to the3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein isthought to associate with the nuclear corepressor/histonedeacetylase complex to block hematopoietic differentiation. Theprotein encoded by this gene binds to the AML1-MTG8 complex and maybe important in promoting leukemogenesis. Several transcriptvariants are thought to exist for this gene, but the full-lengthnatures of only three have been described.


Guastadisegni, M.C., et al. Leukemia 24(8):1516-1519(2010)Ossovskaya, V.S., et al. J. Neurosci. Methods 177(2):322-333(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Olsson, A., et al. Biochim. Biophys. Acta 1779(10):590-598(2008)Kumar, R., et al. Mol. Cancer Res. 4(9):655-665(2006)

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$ 80.00
Cat# BP16252a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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