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CC2D1A Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6P1N0
Clone Names 100528145
Peptide ID 100528145
Additional Information
Gene ID 54862
Other Names Coiled-coil and C2 domain-containing protein 1A, Akt kinase-interacting protein 1, Five prime repressor element under dual repression-binding protein 1, FRE under dual repression-binding protein 1, Freud-1, Putative NF-kappa-B-activating protein 023N, CC2D1A, AKI1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CC2D1A
Synonyms AKI1
Function Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Cellular Location Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q66HA5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)

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CC2D1A is a transcriptional repressor that bindsto a conserved 14-bp 5'-repressor element and regulates expressionof the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronalcells. The DNA binding and transcriptional repressor activities ofthe protein are inhibited by calcium. A mutation in this generesults in nonsyndromic mental retardation-3.


Zhao, M., et al. J. Biol. Chem. 285(32):24372-24380(2010)Nakamura, A., et al. Biochem. Biophys. Res. Commun. 393(4):872-876(2010)Nakamura, A., et al. J. Cell Biol. 187(5):607-614(2009)McKay, G.J., et al. Invest. Ophthalmol. Vis. Sci. 50(2):533-539(2009)Rogaeva, A., et al. Eur. J. Neurosci. 26(4):965-974(2007)

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$ 80.00
Cat# BP16254a
Availability: In Stock
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