|Other Names||Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, Activin receptor-like kinase 6, ALK-6, Serine/threonine-protein kinase receptor R6, SKR6, CDw293, Bmpr1b, Acvrlk6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149).|
|Cellular Location||Cell membrane. Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1.
Chiang, P.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16320-16324(2010)Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010)Libusova, L., et al. Development 137(14):2297-2305(2010)Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)
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