|Other Names||Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, Activin receptor-like kinase 6, ALK-6, Serine/threonine-protein kinase receptor R6, SKR6, CDw293, Bmpr1b, Acvrlk6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1.
Chiang, P.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16320-16324(2010)Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010)Libusova, L., et al. Development 137(14):2297-2305(2010)Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.