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Mouse Cdk10 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q3UMM4 |
|---|---|
| Clone Names | 110316081 |
| Gene ID | 234854 |
|---|---|
| Other Names | Cyclin-dependent kinase 10, Cell division protein kinase 10, Cdk10 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Cdk10 |
|---|---|
| Function | Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. |
| Cellular Location | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q15131} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cdk10 belongs to the CDK(cyclin-dependent kinase) subfamily of the Ser/Thr protein kinasefamily. The CDK subfamily members are highly similar to the geneproducts of S. cerevisiae cdc28, and S. pombe cdc2, and are knownto be essential for cell cycle progression. The human ortholog hasbeen shown to play a role in cellular proliferation. Multipletranscript variants encoding different isoforms have been found forthis gene. A related pseudogene exists on chromosome 1. [providedby RefSeq].
References
Bagella, L., et al. J. Cell. Biochem. 99(3):978-985(2006)Grana, X., et al. Oncogene 9(7):2097-2103(1994)
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