|Other Names||Trafficking protein particle complex subunit 2, Sedlin, TRAPPC2, SEDL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment. Nucleus Cytoplasm. Note=Localized in perinuclear granular structures.|
|Tissue Location||Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
TRAPPC2 is thought to be part ofa large multi-subunit complex involved in the targeting and fusionof endoplasmic reticulum-to-Golgi transport vesicles with theiracceptor compartment. In addition, the encoded protein can bindc-myc promoter-binding protein 1 and block its transcriptionalrepression capability. Mutations in this gene are a cause ofspondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogeneof this gene is located on chromosome 19, and other pseudogenes arefound on chromosomes 8 and Y.
Liu, X., et al. J. Cell. Biochem. 109(6):1129-1133(2010)Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :Guo, H., et al. J. Genet. 88(1):87-91(2009)Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)
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