|Other Names||Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment|
|Tissue Location||Expressed in brain, placenta, kidney, neuron and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
PNPLA6 is a phospholipase that deacetylatesintracellular phosphatidylcholine to produce glycerophosphocholine.It is thought to function in neurite outgrowth and processelongation during neuronal differentiation. The protein is anchoredto the cytoplasmic face of the endoplasmic reticulum in bothneurons and non-neuronal cells. Mutations in this gene result inautosomal recessive spastic paraplegia, and the protein is thetarget for neurodegeneration induced by organophosphorus compoundsand chemical warfare agents. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
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