PNPLA6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IY17 |
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Clone Names | 100318192 |
Gene ID | 10908 |
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Other Names | Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PNPLA6 (HGNC:16268) |
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Synonyms | NTE |
Function | Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein |
Tissue Location | Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
PNPLA6 is a phospholipase that deacetylatesintracellular phosphatidylcholine to produce glycerophosphocholine.It is thought to function in neurite outgrowth and processelongation during neuronal differentiation. The protein is anchoredto the cytoplasmic face of the endoplasmic reticulum in bothneurons and non-neuronal cells. Mutations in this gene result inautosomal recessive spastic paraplegia, and the protein is thetarget for neurodegeneration induced by organophosphorus compoundsand chemical warfare agents. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
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