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PNPLA6 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IY17
Clone Names 100318192
Additional Information
Gene ID 10908
Other Names Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PNPLA6 (HGNC:16268)
Synonyms NTE
Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584).
Cellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein
Tissue Location Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain
Research Areas
Citations (0)
citation

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Background

PNPLA6 is a phospholipase that deacetylatesintracellular phosphatidylcholine to produce glycerophosphocholine.It is thought to function in neurite outgrowth and processelongation during neuronal differentiation. The protein is anchoredto the cytoplasmic face of the endoplasmic reticulum in bothneurons and non-neuronal cells. Mutations in this gene result inautosomal recessive spastic paraplegia, and the protein is thetarget for neurodegeneration induced by organophosphorus compoundsand chemical warfare agents. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

References

Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)

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$ 277.78
Cat# BP16273b
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