|Other Names||60S ribosomal protein L12, RPL12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds directly to 26S ribosomal RNA.|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L11P family of ribosomal proteins. It is located in thecytoplasm. The protein binds directly to the 26S rRNA. This gene isco-transcribed with the U65 snoRNA, which is located in its fourthintron. As is typical for genes encoding ribosomal proteins, thereare multiple processed pseudogenes of this gene dispersed throughthe genome.
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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