|Other Names||Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).|
|Cellular Location||Cytoplasm. Midbody. Note=Transiently associated with endosomes (PubMed:19580544). Colocalized with IST1 to the ends of Flemming bodies during cytokinesis (PubMed:20719964)|
|Tissue Location||Ubiquitously expressed, with highest levels of expression detected in adipose tissue|
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SPG20 is a protein containing a MIT (MicrotubuleInteracting and Trafficking molecule) domain, and is implicated inregulating endosomal trafficking and mitochondria function. Theprotein localizes to mitochondria and partially co-localizes withmicrotubules. Stimulation with epidermal growth factor (EGF)results in protein translocation to the plasma membrane, and theprotein functions in the degradation and intracellular traffickingof EGF receptor. Multiple alternatively spliced variants, encodingthe same protein, have been identified. Mutations associated withthis gene cause autosomal recessive spastic paraplegia 20 (Troyersyndrome).
Hooper, C., et al. BMC Biol. 8, 72 (2010) :Milewska, M., et al. J. Neurochem. 111(4):1022-1030(2009)Tsang, H.T., et al. Hum. Mol. Genet. 18(20):3805-3821(2009)Edwards, T.L., et al. Biochem. J. 423(1):31-39(2009)Eastman, S.W., et al. J. Cell Biol. 184(6):881-894(2009)
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