|Other Names||E3 ubiquitin-protein ligase RNF4, 632-, RING finger protein 4, Small nuclear ring finger protein, Protein SNURF, RNF4, SNURF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm|
|Tissue Location||Widely expressed at low levels in many tissues; highly expressed in testis.|
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The protein encoded by this gene contains a RING fingermotif and acts as a transcription regulator. This protein has beenshown to interact with, and inhibit the activity of, TRPS1, atranscription suppressor of GATA-mediated transcription.Transcription repressor ZNF278/PATZ is found to interact with thisprotein, and thus reduce the enhancement of androgenreceptor-dependent transcription mediated by this protein. Studiesof the mouse and rat counterparts suggested a role of this proteinin spermatogenesis. A pseudogene of this gene is found onchromosome 1.
Hu, X.V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15087-15092(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Salonen, J., et al. Mol. Cell. Endocrinol. 307 (1-2), 205-210 (2009) :Percherancier, Y., et al. J. Biol. Chem. 284(24):16595-16608(2009)Tatham, M.H., et al. Nat. Cell Biol. 10(5):538-546(2008)
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