|Other Names||Zinc finger protein basonuclin-1, BNC1, BNC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.|
|Cellular Location||Nucleus. Cytoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.|
|Tissue Location||Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc finger proteinpresent in the basal cell layer of the epidermis and in hairfollicles. It is also found in abundance in the germ cells oftestis and ovary. This protein is thought to play a regulatory rolein keratinocyte proliferation and it may also be a regulator forrRNA transcription. This gene seems to have multiple alternativelyspliced transcript variants, but their full-length nature is notknown yet. There seems to be evidence of multiple polyadenylationsites for this gene.
Vanhoutteghem, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(33):12423-12428(2006)Iuchi, S., et al. Exp. Dermatol. 9(3):178-184(2000)Tang, W., et al. Gene 237(1):35-44(1999)Tseng, H., et al. J. Cell. Sci. 112 PT 18, 3039-3047 (1999) :Iuchi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(17):9628-9632(1999)
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