BNC1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01954 |
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Clone Names | 100324038 |
Gene ID | 646 |
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Other Names | Zinc finger protein basonuclin-1, BNC1, BNC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BNC1 |
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Synonyms | BNC |
Function | Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). |
Cellular Location | Nucleus. Cytoplasm Nucleus, nucleoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids {ECO:0000250|UniProtKB:O35914} |
Tissue Location | In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312) Expressed in the ovary, notably in oocytes (PubMed:30010909) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc finger proteinpresent in the basal cell layer of the epidermis and in hairfollicles. It is also found in abundance in the germ cells oftestis and ovary. This protein is thought to play a regulatory rolein keratinocyte proliferation and it may also be a regulator forrRNA transcription. This gene seems to have multiple alternativelyspliced transcript variants, but their full-length nature is notknown yet. There seems to be evidence of multiple polyadenylationsites for this gene.
References
Vanhoutteghem, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(33):12423-12428(2006)Iuchi, S., et al. Exp. Dermatol. 9(3):178-184(2000)Tang, W., et al. Gene 237(1):35-44(1999)Tseng, H., et al. J. Cell. Sci. 112 PT 18, 3039-3047 (1999) :Iuchi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(17):9628-9632(1999)
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