|Other Names||Membrane progestin receptor alpha, mPR alpha, Progestin and adipoQ receptor family member 7, Progestin and adipoQ receptor family member VII, PAQR7, MRPA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder|
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Provided below are standard protocols that you may find useful for product applications.
PAQR7 is a steroid membrane receptor. Binds progesterone in vitro. It may be involved in oocyte maturation.
Thomas, P., et al. Steroids 74(7):614-621(2009)Smith, J.L., et al. Steroids 73(11):1160-1173(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Thomas, P., et al. Endocrinology 148(2):705-718(2007)Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
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