|Other Names||Zinc transporter ZIP14, LIV-1 subfamily of ZIP zinc transporter 4, LZT-Hs4, Solute carrier family 39 member 14, Zrt- and Irt-like protein 14, ZIP-14, SLC39A14, KIAA0062, ZIP14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, lamellipodium Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae|
|Tissue Location||Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Isoform 1 is ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:15642354, PubMed:7584044, PubMed:27231142). Isoform 3 is widely expressed but not detected in brain, heart, skeletal muscle and fetal skin (PubMed:27231142)|
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Provided below are standard protocols that you may find useful for product applications.
Zinc is an essential cofactor for hundreds of enzymes. Itis involved in protein, nucleic acid, carbohydrate, and lipidmetabolism, as well as in the control of gene transcription,growth, development, and differentiation. SLC39A14 belongs to asubfamily of proteins that show structural characteristics of zinctransporters (Taylor and Nicholson, 2003 [PubMed12659941]).
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Gao, J., et al. J. Biol. Chem. 283(31):21462-21468(2008)Liuzzi, J.P., et al. Proc. Natl. Acad. Sci. U.S.A. 102(19):6843-6848(2005)Taylor, K.M., et al. FEBS Lett. 579(2):427-432(2005)Taylor, K.M., et al. Biochim. Biophys. Acta 1611 (1-2), 16-30 (2003) :
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