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ACPL2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TE99 |
|---|---|
| Clone Names | 100422201 |
| Gene ID | 92370 |
|---|---|
| Other Names | 2-phosphoxylose phosphatase 1, 313-, Acid phosphatase-like protein 2, Xylosyl phosphatase {ECO:0000303|PubMed:24425863, ECO:0000312|EMBL:BAO457951}, epididymis luminal protein 124 {ECO:0000303|Ref2, ECO:0000312|EMBL:ACJ137311}, PXYLP1 (HGNC:26303) |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PXYLP1 (HGNC:26303) |
|---|---|
| Function | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Note=Colocalizes to Golgi apparatus in a B3GAT3- dependent manner. |
| Tissue Location | Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the histidine acid phosphatase family
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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