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FAM38B Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H5I5 |
|---|---|
| Clone Names | 100422275 |
| Gene ID | 63895 |
|---|---|
| Other Names | Piezo-type mechanosensitive ion channel component 2, Protein FAM38B, PIEZO2, C18orf30, C18orf58, FAM38B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIEZO2 (HGNC:26270) |
|---|---|
| Function | Pore-forming subunit of a mechanosensitive non-specific cation channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8CD54}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CD54} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Piezos are large transmembrane proteins conserved amongvarious species, all having between 24 and 36 predictedtransmembrane domains. 'Piezo' comes from the Greek 'piesi,'meaning 'pressure.' The PIEZO2 protein has a role in rapidlyadapting mechanically activated (MA) currents in somatosensoryneurons (Coste et al., 2010 [PubMed 20813920]).
References
Coste, B., et al. Science 330(6000):55-60(2010)Brandenberger, R., et al. Nat. Biotechnol. 22(6):707-716(2004)
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