|Other Names||Histone-binding protein RBBP7, Histone acetyltransferase type B subunit 2, Nucleosome-remodeling factor subunit RBAP46, Retinoblastoma-binding protein 7, RBBP-7, Retinoblastoma-binding protein p46, RBBP7, RBAP46|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.|
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This protein is a ubiquitously expressed nuclear proteinand belongs to a highly conserved subfamily of WD-repeat proteins.It is found among several proteins that binds directly toretinoblastoma protein, which regulates cell proliferation. Theencoded protein is found in many histone deacetylase complexes,including mSin3 co-repressor complex. It is also present in proteincomplexes involved in chromatin assembly. This protein can interactwith BRCA1 tumor-suppressor gene and may have a role in theregulation of cell proliferation and differentiation. Twotranscript variants encoding different isoforms have been found forthis gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Saade, E., et al. Proteomics 9(21):4934-4943(2009)Wang, C.L., et al. J. Proteome Res. 8(10):4428-4440(2009)Li, R., et al. EMBO J. 28(18):2763-2776(2009)
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