|Other Names||DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.|
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The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by the MCM proteins is a keycomponent of the pre-replication complex (pre_RC) and may beinvolved in the formation of replication forks and in therecruitment of other DNA replication related proteins. The MCMcomplex consisting of this protein and MCM2, 4 and 6 proteinspossesses DNA helicase activity, and may act as a DNA unwindingenzyme. Cyclin D1-dependent kinase, CDK4, is found to associatewith this protein, and may regulate the binding of this proteinwith the tumorsuppressor protein RB1/RB. Alternatively splicedtranscript variants encoding distinct isoforms have been reported.
Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)Kim, D.W., et al. Mol. Biochem. Parasitol. 173(1):10-16(2010)Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Rojiani, M.V., et al. Appl. Immunohistochem. Mol. Morphol. 18(3):278-282(2010)Poliseno, L., et al. Sci Signal 3 (117), RA29 (2010) :
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