|Other Names||Smoothened homolog, SMO, Protein Gx, SMO, SMOH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell projection, cilium|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G protein-coupledreceptor that interacts with the patched protein, a receptor forhedgehog proteins. The encoded protein tranduces signals to otherproteins after activation by a hedgehog protein/patched proteincomplex.
Zhang, L., et al. Oral Dis 16(8):818-822(2010)Desch, P., et al. Oncogene 29(35):4885-4895(2010)Walter, K., et al. Clin. Cancer Res. 16(6):1781-1789(2010)Hirotsu, M., et al. Mol. Cancer 9, 5 (2010) :Rittie, L., et al. Aging Cell 8(6):738-751(2009)
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