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BOLL Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N9W6 |
|---|---|
| Clone Names | 100528230 |
| Gene ID | 66037 |
|---|---|
| Other Names | Protein boule-like, BOLL, BOULE |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BOLL |
|---|---|
| Synonyms | BOULE |
| Function | Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis |
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Provided below are standard protocols that you may find useful for product applications.
Background
BOLL belongs to the DAZ gene family required for germcell development. It encodes an RNA-binding protein which is moresimilar to Drosophila Boule than to human proteins encoded by genesDAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like).Loss of this gene function results in the absence of sperm in semen(azoospermia). Histological studies demonstrated that the primarydefect is at the meiotic G2/M transition.
References
Chen, P., et al. J. Androl. 31(2):163-168(2010)Kee, K., et al. Nature 462(7270):222-225(2009)Lin, Y.M., et al. J. Clin. Endocrinol. Metab. 94(7):2650-2657(2009)Bilguvar, K., et al. Nat. Genet. 40(12):1472-1477(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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