|Other Names||Protein boule-like, BOLL, BOULE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).|
|Tissue Location||Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.|
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BOLL belongs to the DAZ gene family required for germcell development. It encodes an RNA-binding protein which is moresimilar to Drosophila Boule than to human proteins encoded by genesDAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like).Loss of this gene function results in the absence of sperm in semen(azoospermia). Histological studies demonstrated that the primarydefect is at the meiotic G2/M transition.
Chen, P., et al. J. Androl. 31(2):163-168(2010)Kee, K., et al. Nature 462(7270):222-225(2009)Lin, Y.M., et al. J. Clin. Endocrinol. Metab. 94(7):2650-2657(2009)Bilguvar, K., et al. Nat. Genet. 40(12):1472-1477(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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