|Other Names||GDNF family receptor alpha-3, GDNF receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, GFRA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.|
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Provided below are standard protocols that you may find useful for product applications.
GFRA3 is aglycosylphosphatidylinositol(GPI)-linked cell surface receptor anda member of the GDNF receptor family. It forms a signaling receptorcomplex with RET tyrosine kinase receptor and binds the ligand,artemin.
Souza, R.P., et al. J Psychiatr Res 44(11):700-706(2010)Zhu, D.L., et al. Nan Fang Yi Ke Da Xue Xue Bao 29(3):428-432(2009)Wang, X., et al. Structure 14(6):1083-1092(2006)Yang, C., et al. J. Mol. Histol. 37 (1-2), 69-77 (2006) :Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
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