|Other Names||BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, Silencer of death domains, BAG4, SODD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
BAG4 is a member of theBAG1-related protein family. BAG1 is an anti-apoptotic protein thatfunctions through interactions with a variety of cell apoptosis andgrowth related proteins including BCL-2, Raf-protein kinase,steroid hormone receptors, growth factor receptors and members ofthe heat shock protein 70 kDa family. This protein contains a BAGdomain near the C-terminus, which could bind and inhibit thechaperone activity of Hsc70/Hsp70. This protein was found to beassociated with the death domain of tumor necrosis factor receptortype 1 (TNF-R1) and death receptor-3 (DR3), and thereby negativelyregulates downstream cell death signaling. The regulatory role ofthis protein in cell death was demonstrated in epithelial cellswhich undergo apoptosis while integrin mediated matrix contacts arelost.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Tao, H.F., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15(3):501-505(2007)Riley, B.M., et al. Am. J. Med. Genet. A 143A (8), 846-852 (2007) :Yang, Z.Q., et al. Cancer Res. 66(24):11632-11643(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.