|Other Names||Erythropoietin, Epoetin, EPO|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|
|Tissue Location||Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals|
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Provided below are standard protocols that you may find useful for product applications.
EPO is a member of the EPO/TPO family and encodes asecreted, glycosylated cytokine composed of four alpha helicalbundles. The protein is found in the plasma and regulates red cellproduction by promoting erythroid differentiation and initiatinghemoglobin synthesis. This protein also has neuroprotectiveactivity against a variety of potential brain injuries andantiapoptotic functions in several tissue types. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kristensen, P.L., et al. Eur. J. Endocrinol. 163(3):391-398(2010)Kim, M.H., et al. Mol. Biol. (Mosk.) 44(4):656-663(2010)Carraway, M.S., et al. Circ. Res. 106(11):1722-1730(2010)Shi, Z., et al. Mol. Cancer Res. 8(4):615-626(2010)
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